Advances in Neuroprotective Strategies: Potential Therapies for Intracerebral Hemorrhage

Advances in neuroprotective strategies: potential therapies for intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) is associated with higher mortality and morbidity than any other form of stroke. However, there currently are no treatments proven to improve outcomes after ICH, and therefore, new effective therapies are urgently needed. Growing insight into ICH pathophysiology has led to the development of neuroprotective strategies that aim to improve the outcome through reduct...

Neuroprotective strategies for intracerebral hemorrhage: trials and translation.

Intracerebral hemorrhage is a devastating neurological illness with few treatment options. In the past 10 years, 6 clinical trials have been completed examining the potential role that putative neuroprotective agents might play in improving outcome. Although each of these trials failed to show a benefit, animal research continues to supply the translational pipeline and 5 clinical trials evalua...

Advances in intracerebral hemorrhage management.

Recent advances in the evaluation and management of intracerebral hemorrhage (ICH) include: the identification of molecular markers that correlate with events in its early course, complications, and outcome; the impact of previous treatment with antiplatelet or anticoagulant agents on the outcome after ICH; the analysis of the results of the large international STICH (Surgical Trial in Intracer...

[Somatosensory evoked potential in experimental intracerebral hemorrhage].

Neurobiology of Disease Neuroprotective Role of Haptoglobin after Intracerebral Hemorrhage

After intracerebral hemorrhage (ICH), the brain parenchyma is exposed to blood containing red blood cells (RBCs) and consequently to its lysis products. Iron-rich hemoglobin (Hb) is the most abundant protein in RBCs. When released into the brain parenchyma during hemolysis, Hb becomes a central mediator of cytotoxicity. Our study indicates that haptoglobin (Hp), an acute-phase response protein ...